What is the administration protocol for tPA regarding bolus and infusion time?

The administration protocol for tissue plasminogen activator (tPA), a critical treatment for eligible patients with ischemic stroke, includes a bolus followed by a period of continuous infusion. The recommended protocol is to administer a 1-minute bolus of tPA, which allows for rapid delivery of the medication into the patient's bloodstream. Following this initial bolus, the drug is infused over a 60-minute period. This specific timing is crucial, as it maximizes the drug's effectiveness in dissolving the blood clot that is obstructing cerebral blood flow, while also monitoring the patient closely for any potential adverse effects, such as bleeding.

The infusion time of 60 minutes is particularly important as it extends the duration that tPA can act in the system, providing a sustained effect necessary for optimal breakdown of the clot. This aligns with guidelines established by major stroke treatment initiatives and organizations to ensure consistency in treatment and outcomes for patients experiencing strokes.