What is the correct method to reconstitute TNK?

The correct method to reconstitute Tenecteplase (TNK) involves using sterile water for injection. When reconstituting TNK, it's crucial to follow the manufacturer's instructions, which specify using 10 cc of sterile water. This ensures that the medication is properly diluted to achieve the appropriate concentration for administration.

After adding the sterile water to the vial containing the lyophilized TNK, gently swirling (not shaking) the vial is recommended to ensure complete dissolution. Shaking can introduce air bubbles and increase the potential for denaturation of the protein, which can affect the efficacy of the drug.

Reconstituting the medication correctly is vital for ensuring patient safety and treatment effectiveness, as improper reconstitution can lead to incorrect dosing, decreased drug efficacy, or an increased risk of complications. Therefore, the method that specifies adding 10 cc of sterile water, followed by swirling to mix, is the appropriate procedure.