What is the recommended time frame for administering tPA in eligible stroke patients?

The recommended time frame for administering tPA (tissue Plasminogen Activator) to eligible stroke patients is within 4.5 hours of symptom onset. This time frame is critical because tPA is a clot-busting medication that is most effective when given shortly after the onset of stroke symptoms. The efficacy of the treatment diminishes significantly beyond this window, making early intervention essential to improving outcomes for patients.

The 4.5-hour limit is based on clinical evidence that demonstrates a balance between the benefits of thrombolysis and the risks, particularly the risk of bleeding complications. Administering tPA within this timeframe allows healthcare providers to maximize the therapeutic effects while minimizing potential adverse effects, such as hemorrhage. This guideline is endorsed by major stroke treatment guidelines and organizations focused on improving the care and outcomes for stroke patients.