What is the tPA dosing for a patient weighing over 220 pounds?

The dosing of tissue plasminogen activator (tPA) for acute ischemic stroke is based on the patient’s weight, following the established protocols to maximize efficacy while minimizing risks. For patients weighing over 220 pounds, the correct approach is to administer the full dose of tPA, which consists of a 9 mg bolus and a 81 mg infusion over the following hour.

This dosing regimen is consistent with the guidelines formulated by the American Heart Association and American Stroke Association. Administering the full dose allows for the best chance of reperfusion of the occluded vessel, which is crucial for restoring blood flow to the brain and minimizing long-term neurological damage.

The other options do not adhere to these recommended guidelines. Administering only a half dose or a 9 mg bolus fails to deliver the potentially life-saving benefits the full dose can offer. Additionally, no treatment being provided would be inappropriate because treatment with tPA is often indicated unless contraindications exist.